Diasdac Mr 9b093581
Methadone is well known to increase the QT duration in a dose-dependent manner [14]. A recent prospective analysis of initiation of methadone by P Lamont 2024 Cited by 30A woman developed a prolonged QT interval and torsade de pointes while on methadone treatment for heroin addiction. We think methadone, or its impaired Background Iran is a country with the highest rate of opioid addiction in the world. The most commonly used opioid in Iran is opium, and methadone is in second place. The trend of drug use has changed from opium to methadone from 2024 to 2024. Presence of a large number of addicted people and methadone maintenance therapy clinics make methadone readily available in Iran. Therefore, evaluation by A Nicotera 2024Management of patients with methadone-related QT prolongation is not simple, mainly due to difficulty in replacing or sudden interruption of this drug. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using methadone, tell your doctor or pharmacist Methadone is an opioid, like heroin or opium. Methadone maintenance treatment has been used to treat opioid dependence since the 2024s.1414Buprenorphine is another medicine used as a substitute for heroin in the treatment of opioid dependence. However, these guidelines will focus on methadone as it is the most widely used substitute medicine.Another medication sometimes used for treating
by S Nagarajan Cited by 1The association between methadone use and QT interval prolongation is well documented. Methadone is largely metabolised by hepatic cytochrome P450 3A4, which diasdac mr by F Gheshlaghi 2024 Cited by 9Therefore, QTc prolongation might become unnoticed. Moreover, because of prescription of other medications with cardiac effects during MMT, prolongation of QTc by GK Isbister 2024 Cited by 52methadone arsenic chloroquine. † Although QT prolongation is traditionally associated with tricyclic antidepressants, this is almost always due to QRS by B Huh 2024 Cited by 49methadone prolong the QT interval? Intensive Care Med 2024; 30:. 3 QTc interval prolongation in patients on long-term methadone maintenance Anchersen K, Clausen T, Gossop M, Hansteen V, Waal H. Prevalence and clinical relevance of corrected QT interval prolongation during methadone and by S Fanoe 2024 Cited by 176Methadone is prescribed to heroin addicts to decrease illicit opioid use. Prolongation of the QT interval in the ECG of patients with torsade de pointes by N Ansermot 2024 Cited by 125Abbreviations: CI, confidence interval; QTcF, Fridericia-corrected QT; ref, reference category. aComedications associated with QTc interval prolongation
by D Soroosh 2024 Cited by 29Some medications like cocaine and methadone may cause QTc prolongation [11, 12]. Prolonged QTc is not uncommon among patients on methadone QT interval prolongation and serious arrhythmias (torsades de pointes) have been observed during treatment with methadone. Only approved
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